(E)-Ethyl 3-(Tetrahydro-2H-Pyran-4-Yl)Acrylate(WXC02732) synthesis
- Product Name:(E)-Ethyl 3-(Tetrahydro-2H-Pyran-4-Yl)Acrylate(WXC02732)
- CAS Number:99228-16-7
- Molecular formula:C10H16O3
- Molecular Weight:184.23
1768-64-5
131 suppliers
$16.00/1g
74-83-9
2 suppliers
$28.30/1ML
1117-37-9
97 suppliers
$49.00/500g
99228-16-7
14 suppliers
$130.00/50mg
Yield:-
Reaction Conditions:
with magnesium in tetrahydrofuran;
Steps:
8 Preparation of ethyl 1-(4-tetrahydropyranyl)eth-1-ene-2 -carboxylate
Example 8 Preparation of ethyl 1-(4-tetrahydropyranyl)eth-1-ene-2 -carboxylate 9.6 g (400 mmol) of magnesium turnings are covered with tetrahydrofuran, about 2 ml of bromomethane are added, and the mixture is warmed to reflux. 38.45 g (300 mmol) of 4-chlorotetrahydropyran, dissolved in 100 ml of tetrahydrofuran, are added dropwise. The mixture is subsequently stirred for a further 30 minutes and cooled to 10° C., 42.9 g (300 mmol) of ethyl 1-(dimethylamino)eth-1-ene-2-carboxylate are added dropwise, and the mixture is stirred for a further 12 hours. Customary work-up gives 31.4 g (60%) of ethyl 1-(4-tetrahydropyranyl)eth-1-ene-2-carboxylate of boiling point 120° to 140° C./10 mmHg.
References:
US5221753,1993,A
50675-18-8
204 suppliers
$15.00/100mg
867-13-0
459 suppliers
$10.00/1g
99228-16-7
14 suppliers
$130.00/50mg
50675-18-8
204 suppliers
$15.00/100mg
1099-45-2
360 suppliers
$6.00/5g
99228-16-7
14 suppliers
$130.00/50mg