Acetamide, N-(5-amino-2-pyridinyl)-N-methyl- synthesis

Yield:92808-22-5 90.9%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in tetrahydrofuran;methanol at 20; for 12 h;

Steps:

155.3

(3) N-5-(Aminopyridin-2-yl)-N-methylacetamide; A mixture of N-methyl-N-(5-nitropyridin-2-yl)acetamide (1.30 g, 6.66 mmol), 10% palladium-carbon (130 mg), tetrahydrofuran (10 ml) and methanol (10 ml) was stirred under a hydrogen atmosphere for 12 hours and insolubles were filtered off. The filtrate was concentrated to obtain the desired product (1.00 g, 90.9%) as an oil. ¹H-NMR (CDCl₃) δ; 1.93 (3H, s), 3.27 (3H, s), 3.82 (2H, br s), 6.96 - 7.07 (2H, m), 7.96 (1H, d, J = 2.7 Hz).

References:

EP1813606,2007,A1 Location in patent:Page/Page column 85