AKOS B018339 synthesis

Yield:33992-80-2 95%

Reaction Conditions:

with thiourea;urea at 110; for 0.1 h;Neat (no solvent);Knoevenagel condensation;

Steps:

General procedure for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones:

General procedure: A mixture of aldehyde (1 mmol), 2,4-thiazolidinediones/2-thioxothiazolidin-4-ones (1 mmol) using 10 mol % urea/thiourea as catalyst was condensed at 110 °C on oil bath under solvent-free reaction conditions. After completion of the reaction as indicated by TLC, the crude product was cooled, washed with water (10 mL), filtered and recrystallization from ethanol: DMF to afford 3a-ab.

References:

Shah, Sakshi;Singh, Baldev [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 17,p. 5388 - 5391] Location in patent:experimental part