alpha-Chloro-o-fluorotoluene synthesis
- Product Name:alpha-Chloro-o-fluorotoluene
- CAS Number:345-35-7
- Molecular formula:C7H6ClF
- Molecular Weight:144.57
95-52-3
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$10.00/5 g
345-35-7
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$13.43/1gm:
Yield:345-35-7 36%
Reaction Conditions:
with iron(II) chloride tetrahydrate;tert-butylhypochlorite at 20; for 3 h;Inert atmosphere;chemoselective reaction;Reagent/catalyst;
Steps:
4.2. Preparation of mono- and difluorobenzyl chlorides. 4.2.1. General procedures. Method B.
General procedure: The reactions were carried out in a glass reactor (V=20 mL) with continuous stirring at room temperature. The tube under argon was charged with FeCl2·4H2O (0.18 mmol, 0.036 g), synthesized authentic tert-butyl hypochlorite [22] (54 mmol,5.88 g) and fluorotoluene 1-3 (18 mmol, (2.00 g) (or difluorotoluene 4-6 (2.30 g)). The mixture was stirred at r.t. for 3 h. After completion of the reaction, the reaction mixture was filtered through a paper filter. The target product was separated from the initial mono- or difluorotoluene by vacuum distillation.
References:
Bayguzina, Alfiya R.;Gallyamova, Leysan I.;Khalilov, Leonard M.;Khusnutdinov, Ravil I. [Journal of Fluorine Chemistry,2019,vol. 226,art. no. 109346] Location in patent:supporting information
446-51-5
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$8.00/5g
345-35-7
298 suppliers
$13.43/1gm:
445-29-4
412 suppliers
$5.00/10g
345-35-7
298 suppliers
$13.43/1gm: