Benzaldehyde, 4-(2-pyridinyl)-, hydrazone synthesis

Yield: 94%

Reaction Conditions:

with hydrazine hydrate in methanol at 20;

Steps:

5
Example 5; N-[4-(2-pyridyl)phenylmethylidene]hydrazine (19) To a solution of hydrazine hydrate (98%, 7.50 mL, 150 mmol) in MeOH (30 mL) was added dropwise a solution of 4-(2-pyridyl)benzaldehyde (9.16 g, 50 mmol) in MeOH (30 mL) at room temperature. After stirring for 2 h at room temperature, volatile matters were removed under reduced pressure.The residue was crystallized from EtOAc-hexane to give the product (9.27 g, 94%) as colorless crystals.

References:

OXYRANE (UK) LIMITED US2009/270499, 2009, A1 Location in patent:Page/Page column 18