ChemicalBook CAS DataBase List Benzenamine, 4-[4-(3-oxetanyl)-1-piperazinyl]-

Benzenamine, 4-[4-(3-oxetanyl)-1-piperazinyl]- synthesis

7synthesis methods

Product Name:Benzenamine, 4-[4-(3-oxetanyl)-1-piperazinyl]-
CAS Number:1395030-33-7
Molecular formula:C13H19N3O
Molecular Weight:233.31

Piperazine, 1-(4-nitrophenyl)-4-(3-oxetanyl)-

1433823-88-1
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Benzenamine, 4-[4-(3-oxetanyl)-1-piperazinyl]-

1395030-33-7
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$220.00/50mg

Yield:1395030-33-7 98%

Reaction Conditions:

with 10% Pd/C;hydrogen in methanol;dichloromethane; under 2327.23 Torr; for 1.25 h;Inert atmosphere;

Steps:

[0275] 4-(4-(Oxetan-3-yl)piperazin-1-yl)aniline II

[0275] 4-(4-(Oxetan-3-yl)piperazin-1-yl)aniline II: In a hydrogenation vessel, 1- (4-nitrophenyl)-4-(oxetan-3-yl)piperazine I (4.70 g, 17.85 mmoles) was dissolved as much as possible in MeOH (26 mL) and DCM (5 mL). Pd/C (10%) (2.85 g, 2.68 mmoles) was added and the reaction was stored under nitrogen. The reaction was shaken on the Parr hydrogenator at 45 PSI. After 15 minutes, the reaction was fully recharged to 45 PSI and shaken for an additional hour. The material was filtered over celite, washed with 25% MeOH/DCM and concentrated to provide the title compound II as a light brown solid (4.16 g, 17.85 mmoles, 98%).

References:

WO2016/10809,2016,A1 Location in patent:Paragraph 0275