Benzene, 4-bromo-2-chloro-1-(1-methylethyl)- synthesis

Yield:90350-26-8 98%

Reaction Conditions:

with triethylsilane;trifluoroacetic acid in dichloromethane at 20; for 24 h;

Steps:

5.26

Reference Example 5-26 4-Bromo-2-chloro-1-(propan-2-yl)benzene Triethylsilane (1.8 mL) and trifluoroacetic acid (5.8 mL) were added to a solution of 2-(4-bromo-2-chlorophenyl)propan-2-ol (1.9 g) in dichloromethane (76 mL), and the mixture was stirred at room temperature for one day. Water was added to the reaction solution, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and filtered. The solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane only) to give the title compound as a colorless oil (1.74 g, 98%).

References:

US2011/237791,2011,A1 Location in patent:Page/Page column 81