Benzene, 4-fluoro-1-isocyanato-2-methyl- synthesis
2synthesis methods
- Product Name:Benzene, 4-fluoro-1-isocyanato-2-methyl-
- CAS Number:67191-92-8
- Molecular formula:C8H6FNO
- Molecular Weight:151.14
Yield:-
Reaction Conditions:
with triethylamine in tetrahydrofuran;dichloromethane;toluene; for 2 h;
Steps:
23.1
20 % Phosgene in toluene (0.25 mL, 0.48 mmol) and triethylamine (0.11 mL, 0.76 mmol) were added to a solution of 4-fluoro-2-methyl-benzenamine (12 mg, 0.095 mmol) in a mixture of THF (0.30 mL) and DCM (0.10 mL). The reaction was stirred for two hours, then solvents were removed in vacuo and the product used without further purification in the next step.
References:
WO2011/28685,2011,A1 Location in patent:Page/Page column 87; 88
