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ChemicalBook CAS DataBase List Benzeneacetamide, a-hydroxy-N-(4-methoxyphenyl)-
10295-49-5

Benzeneacetamide, a-hydroxy-N-(4-methoxyphenyl)- synthesis

7synthesis methods
-

Yield:10295-49-5 88%

Reaction Conditions:

Stage #1: 4-Methoxyphenyl isocyanate in tetrahydrofuran;hexane at -23 - 0;
Stage #2: with n-butyllithium in tetrahydrofuran;diethyl ether;hexane at -105; for 0.5 h;
Stage #3: benzaldehyde in tetrahydrofuran;diethyl ether;hexane at -105 - 25;Further stages.;

References:

Kambe, Nobuaki;Inoue, Toru;Takeda, Takanobu;Fujiwara, Shin-Ichi;Sonoda, Noboru [Journal of the American Chemical Society,2006,vol. 128,# 39,p. 12650 - 12651]