Benzeneethanol, 4-bromo-3-fluoro- synthesis
- Product Name:Benzeneethanol, 4-bromo-3-fluoro-
- CAS Number:1331944-00-3
- Molecular formula:C8H8BrFO
- Molecular Weight:219.05
942282-40-8
100 suppliers
$18.14/1g
1331944-00-3
9 suppliers
inquiry
Yield:1331944-00-3 89.8%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 20; for 2 h;
Steps:
5.1; 291.1 Step 1: 2-(4-bromo-3-fluorophenyl)ethan-1-ol
To a solution of 2-(4-bromo-3-fluorophenyl)acetic acid (45.0 g,193 mmol)in THF (270 mL) was added BH 3.THF (1 M,386 mL)at 0 . Then the mixture was stirred at 20 for 2 hrs. Under cooling with ice, MeOH (250 mL) was dropwise added until there was no foaming in the system and the solvent was distilled off under reduced pressure. To the resulting reside, water (50.0mL) was added for extraction with EtOAc (1000.0 mL) . The combined organic phase was washed with brine (40.0 mL) , dried over Na 2SO 4, filtered and concentrated in vacuum. 2-(4-bromo-3-fluorophenyl)ethan-1-ol (38.0 g, 89.8%) was obtained. 1HNMR (400 MHz, CDCl 3-d) δ ppm 7.45 (t, J = 7.72 Hz,1 H) ,7.00 (dd, J = 9.48,1.76 Hz,1 H) ,6.86 -6.92 (m,1 H) ,3.82 (t, J = 6.50 Hz,2 H) ,2.80 (t, J = 6.50 Hz,2 H) ,2.03 (s,1 H) ; [M+H] + = 219.
References:
WO2022/12622,2022,A1 Location in patent:Page/Page column 141-142; 224
942282-41-9
34 suppliers
$163.00/250mg
1331944-00-3
9 suppliers
inquiry
499983-13-0
102 suppliers
inquiry
1331944-00-3
9 suppliers
inquiry
127425-73-4
127 suppliers
$7.00/250mg
1331944-00-3
9 suppliers
inquiry