Benzenemethanamine, N-(2-methyl-4-nitrophenyl)- synthesis
- Product Name:Benzenemethanamine, N-(2-methyl-4-nitrophenyl)-
- CAS Number:201157-13-3
- Molecular formula:C14H14N2O2
- Molecular Weight:242.27
Yield:201157-13-3 93%
Reaction Conditions:
with hexamethylenetetramine-functionalized silica-coated magnetic nano-Fe3O4 core-shell nanocatalyst in ethanol at 60; for 5 h;
Steps:
2.6. General procedure for N-benzylation and N,N-dibenzylation ofprimary amines
General procedure: A mixture of aniline (1eq), benzyl bromide (2.2 eq) and 0.06 gFe3O4SiO2Propyl-HMTA in EtOH (5 mL) was heated at 60 C.After completion of the reaction, as indicated by the TLC (n-hexane/acetone 10:3), the reaction mixture was cooled to room temperatureand the nanocatalyst was separated using an external magnet.The crude product washed with ethanol and purified by hotethanol. The products were characterized using physical andspectroscopic (IR, NMR, MS) data.2.6.1. N,N-dibenzyl-4-chloroaniline 4aWhite solid; Yield: 93%; M. p. 104e105 C;
References:
Ghorbani-Vaghei, Ramin;Mirzaei-Mosbat, Maryam;Noori, Samira [Journal of Molecular Structure,2020,vol. 1219]
