Benzenepropanoic acid, 4-nitro-, hydrazide synthesis
- Product Name:Benzenepropanoic acid, 4-nitro-, hydrazide
- CAS Number:34547-21-2
- Molecular formula:C9H11N3O3
- Molecular Weight:209.2
16642-79-8
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Yield: 85.01%
Reaction Conditions:
with hydrazine hydrate in ethanol;water at 85; for 28 h;Temperature;
Steps:
4 Preparation of Compound III:
In the reaction flask, 3-(4-nitrophenyl)propionic acid (11.7 g, 60 mmol) was added.Ethanol (100 ml), the mixture was stirred well, and then an aqueous solution of hydrazine hydrate (16 ml, 80%) was added. After the temperature was raised to 85 ° C, the reaction was refluxed for 28 h.The progress of the reaction was detected by TLC dot plate, and after the reaction was completed,Transfer the system to a single-mouth bottle,The solvent was removed by rotary evaporation and then placed in a vacuum oven to dry. Weighing 30.06g,The yield was 85.01%.
References:
Zhuhai Rundou Pharmaceutical Co., Ltd.;Tan Zhijun;Wang Qingqing;Dong Xuelin;Qi Honglin;Huang Xiaoyan;Cai Qiang;Zhou Lixin CN109206381, 2019, A Location in patent:Paragraph 0021; 0022
54405-42-4
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34547-21-2
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