Benzoic acid, 4-acetyl-2-hydroxy- synthesis
- Product Name:Benzoic acid, 4-acetyl-2-hydroxy-
- CAS Number:107806-82-6
- Molecular formula:C9H8O4
- Molecular Weight:180.16
27475-11-2
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107806-82-6
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Yield:107806-82-6 78%
Reaction Conditions:
with lithium hydroxide monohydrate;lithium hydroxide monohydrate in tetrahydrofuran;methanol at 20;
Steps:
181 Intermediate 4: 2-(1-((5-(1-methyl-1H-indazole-5-carboxamido)-1H-benzo[d]imidazol-2- yl)methyl)pyrrolidin-3-yl)acetic acid
General procedure: To a solution of intermediate 3 (300 mg, 0.67mmol) in 5 mL MeOH, 5 mL H2O, and 5 mL THF, LiOH (30 mg, 1 mmol) was added. The mixture was stirred at RT overnight. Then the mixture was purified by reverse phase C18 column (10% - 100% methanol / 0.1% TFA in water) to afford intermediate 4 as white solid in TFA salt form (486 mg, 89%).
References:
WO2022/86937,2022,A1 Location in patent:Page/Page column 90-92; 207
586-89-0
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107806-82-6
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1432-42-4
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$45.00/50mg
107806-82-6
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860554-21-8
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107806-82-6
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860575-80-0
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