Benzonitrile, 2-chloro-4-(trifluoromethoxy)- synthesis
- Product Name:Benzonitrile, 2-chloro-4-(trifluoromethoxy)-
- CAS Number:874482-94-7
- Molecular formula:C8H3ClF3NO
- Molecular Weight:221.56
Yield:874482-94-7 220 mg
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide at 120; for 2 h;Inert atmosphere;
Steps:
B SteQ B. 2-Choro-4-(trfluoromethoxy)benzonftre.
2-Choro-4-(trfl uoromethoxy) phenytrfluoromethanesufonate was dssoved n DM F (4.0 mL), foflowed by add Won of zinc cyanide (681 mg, 5.8 mmo) and (Pd(PPh3)4) (335 mg, 0.3 mmo). The reacfionmixture was degassed w[th nftrogen for 10 rnnutes and then heated at 120 C for 2h. After coohng to rt, the crude reacUon mixture was duted w[th saturated aqueous NaHCO3 souUon, and extracted w[th EtOAc (x 3). The combined organic extracts were dried over Na2SO4 and concentrated. PurWcaUon (FCC, SO2 0-5% EtOAc/hexanes) provided the tWe compound as an oH (220 mg, 34% yed). 1H NMR (500 MHz, DMSO-d6) ? 8.16 (d, J =8.7 Hz, I H), 7.93 (dd, J = 2.2, 1.0 Hz, I H), 7.66 -6.56 (m, 1 H),
References:
WO2016/176463,2016,A1 Location in patent:Page/Page column 67
70783-75-4
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