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ChemicalBook CAS DataBase List Benzonitrile, 4-amino-2,6-dimethyl- (9CI)
114820-10-9

Benzonitrile, 4-amino-2,6-dimethyl- (9CI) synthesis

5synthesis methods
4703-15-5 Synthesis
N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide

4703-15-5
38 suppliers
$70.00/100mg

Benzonitrile, 4-amino-2,6-dimethyl- (9CI)

114820-10-9
27 suppliers
inquiry

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: nitric acid; sodium nitrite; acetic acid / water / 4 h / 100 °C
2: sulfuric acid / 1 h / 50 °C
3: t-butylnitrite / dimethyl sulfoxide / 18 h / 50 °C
4: iron; ammonium chloride / water; ethanol / 18 h / 80 °C

References:

Shire Human Genetic Therapies, Inc. US2021/78999, 2021, A1