bermoprofen synthesis
- Product Name:bermoprofen
- CAS Number:78499-27-1
- Molecular formula:C18H16O4
- Molecular Weight:296.32
78490-40-1
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78499-27-1
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Yield:78499-27-1 65.3%
Reaction Conditions:
with PPA in water;
Steps:
1 dl-2-(8-Methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid (compound A):
EXAMPLE 1 dl-2-(8-Methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid (compound A): A mixture of dl-2-[4-(2'-carboxymethyl-4'-methylphenoxy)phenyl]propionic acid (15.3 g) and polyphosphoric acid (92 g) was heated with stirring at 110°-120° C. for 2 hours. To the reaction mixture was added water and the resulting mixture was extracted with chloroform. The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated. The residue was chromatographed on silica gel (75 g) using chloroform as an eluent to give a crude product, which was recrystallized from toluene to give the title compound (9.4 g, 65.3%), m.p. 128°-129° C.
References:
US4238620,1980,A
52107-82-1
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78499-27-1
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65784-33-0
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78499-27-1
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78490-39-8
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78499-27-1
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