BIPHENYL-2-YL-HYDRAZINE HYDROCHLORIDE synthesis

Yield:109221-95-6 77%

Reaction Conditions:

Stage #1: 2-phenylanilinewith hydrogenchloride;sodium nitrite in water at 0; for 0.5 h;Inert atmosphere;
Stage #2: with tin(II) chloride dihdyrate in water at 25; for 2 h;Inert atmosphere;

References:

Saraswati, A. Prasanth;Relitti, Nicola;Brindisi, Margherita;Osko, Jeremy D.;Chemi, Giulia;Federico, Stefano;Grillo, Alessandro;Brogi, Simone;McCabe, Niamh H.;Turkington, Richard C.;Ibrahim, Ola;O'Sullivan, Jeffrey;Lamponi, Stefania;Ghanim, Magda;Kelly, Vincent P.;Zisterer, Daniela;Amet, Rebecca;Hannon Barroeta, Patricia;Vanni, Francesca;Ulivieri, Cristina;Herp, Daniel;Sarno, Federica;Di Costanzo, Antonella;Saccoccia, Fulvio;Ruberti, Giovina;Jung, Manfred;Altucci, Lucia;Gemma, Sandra;Butini, Stefania;Christianson, David W.;Campiani, Giuseppe [ACS Medicinal Chemistry Letters,2020,vol. 11,# 11,p. 2268 - 2276] Location in patent:supporting information