Bixafen| synthesis
- Product Name:Bixafen|
- CAS Number:581809-46-3
- Molecular formula:C18H12Cl2F3N3O
- Molecular Weight:414.21
141573-96-8
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581809-46-3
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Yield:581809-46-3 99%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in toluene at 60; for 4 h;Temperature;Reagent/catalyst;Solvent;
Steps:
1.3; 2.3; 3.3 Step 3
Dissolve (48.65 g, 0.19 mol) of the intermediate 3',4'-dichloro-5-fluoro-2-benzidine in 500 ml of solvent toluene, and add the catalyst N,N-diisopropylethylamine. (24.55 g, 0.19 mol), 1-methyl-3-difluoromethyl-4-pyrazolecarbonyl chloride (36.96 g, 0.19 mol) was added with stirring at 60 ° C, and reacted at 60 ° C for 4 h, cooled after reaction. The reaction liquid was washed with water at room temperature, and the organic phase was separated, dried, concentrated by rotary evaporation, and recrystallized to give 77.91 g of the above-mentioned bixafen, yield: 99%.
References:
CN110117256,2019,A Location in patent:Paragraph 0023; 0027; 0028; 0032; 0033
141573-95-7
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877179-04-9
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581809-46-3
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$100.00/50mg
877179-04-9
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$228.00/250mg
1089212-38-3
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201230-82-2
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131112-05-5
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581809-46-3
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151169-75-4
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581809-46-3
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$100.00/50mg