BOC-GLY-OCS SALT synthesis

Yield:-

Reaction Conditions:

with caesium carbonate in water at 20; for 0.166667 h;

Steps:

3.a Preparation of starting materials; N-(tert-Butoxycarbonyl)glycine cesium salt

To a mixture of N-(tert-butoxycarbonyl)glycine (42.0 g) in water (250 ml) was added cesium carbonate (39.1 g). The mixture was stirred at room temperature for 10 minutes. The water was removed by azeotropic distillation with toluene to give the title product

References:

EP1204323,2004,B1 Location in patent:Page 17