ChemicalBook CAS DataBase List BOC-(R)-ALPHA-PROPYNYL-PROLINE

BOC-(R)-ALPHA-PROPYNYL-PROLINE synthesis

2synthesis methods

Product Name:BOC-(R)-ALPHA-PROPYNYL-PROLINE
CAS Number:959578-39-3
Molecular formula:C13H19NO4
Molecular Weight:253.29

1H,3H-Pyrrolo[1,2-c]oxazol-1-one, tetrahydro-7a-2-propyn-1-yl-3-(trichloromethyl)-, (3R,7aR)-

1003049-46-4
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959578-39-3
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: acetyl chloride / 20 h / Reflux; Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere
3: water; sodium hydroxide / methanol / 3 h / 50 °C / Inert atmosphere

References:

Crick, Peter J.;Simpkins, Nigel S.;Highton, Adrian [Organic Letters,2011,vol. 13,# 24,p. 6472 - 6475]

1,2-Pyrrolidinedicarboxylic acid, 2-(2-propyn-1-yl)-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R)-

1349067-59-9
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959578-39-3
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References

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