C-(4-Trifluoromethyl-pyridin-2-yl)-methylamine synthesis
- Product Name:C-(4-Trifluoromethyl-pyridin-2-yl)-methylamine
- CAS Number:872577-05-4
- Molecular formula:C7H7F3N2
- Molecular Weight:176.14
936841-69-9
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Yield:-
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20;
Steps:
Step C: (4-(Trifluoromethyl)pyridin-2-yl)methanamine
[0209] A mixture of 4-(trifluoromethyl)picolinonitrile (840mg, 4.88 mmol) and 10%Pd/C (168 mg, 0.16 mmol) was stirred under hydrogen (balloon) in MeOH (10 mL) at ambient temperature for overnight. The reaction mixture was filtered through Celite and concentrated to afford (4- (trifluorom ethyl )pyridin-2-yl)methanamine as an oil. LC/MS = 177 [M+l].
References:
WO2016/81290,2016,A1 Location in patent:Paragraph 0209
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