C12H10Cl2N4O synthesis

6synthesis methods

Product Name:C12H10Cl2N4O
CAS Number:761440-08-8
Molecular formula:C12H10Cl2N4O
Molecular Weight:297.14

5750-76-5 Synthesis

5750-76-5
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$5.00/1g

4141-08-6 Synthesis

4141-08-6
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$14.00/1g

761440-08-8
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Yield:761440-08-8 95%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in isopropyl alcohol; for 18 h;Heating / reflux;

Steps:

2

Intermediate 2; 2-[(2,5-Dichloro-4-pyrimidinyl)amino]-N-methylbenzamide A round-bottomed flask was charged with 2,4,5-trichloropyrimidine (2 g, 11.1 mmol), 2-amino-N-methylbenzamide (2 g, 13.3 mmol), di-isopropyl-ethylamine (2.3 mL, 13.3 mmol) and 40 mL isopropanol. The flask was fitted with a reflux condenser and the reaction was heated to reflux and stirred for 18 h. A white solid appeared in the reaction mixture. The reaction was cooled to room temperature, and the solid was filtered off and washed with isopropanol. After drying, the white solid (3.16 g, 10.5 mmol, 95% yield) was identified as 2-[(2,5-dichloro-4-pyrimidinyl)amino]-N-methylbenzamide. MS: M(C₁₂H₁₀Cl₂N₄O)=297.14, (M+H)⁺=297 and 299.

References:

US2008/182852,2008,A1 Location in patent:Page/Page column 7-8

118-48-9 Synthesis