CarboniMidic dichloride, (2,6-dichlorophenyl)- synthesis
- Product Name:CarboniMidic dichloride, (2,6-dichlorophenyl)-
- CAS Number:21709-18-2
- Molecular formula:C7H3Cl4N
- Molecular Weight:242.92
10113-35-6
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21709-18-2
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Yield:21709-18-2 60%
Reaction Conditions:
with thionyl chloride;sulfuryl dichloride at 60; for 10 h;Inert atmosphere;
Steps:
5.2.2. 2,6-Dichloro-1-dichloroisocyano-benzene (3)
The formanilide derivative 2 (9.5 g, 50 mmol) was added slowly to a mixture of SOCl2 (30 mL) and SO2Cl2 (7 g, 51.9 mmol). This solution was stirred and heated at 60 °C for 10 h under a nitrogen atmosphere. SOCl2 was then removed by evaporation under reduced pressure and the residual mixture was distilled to afford 3 (7.28 g, 60%) as a clear yellow liquid: bp = 105 °C; 1H NMR (200 MHz, CDCl3): δ = 7.35 (aro, 2H), 7.09 (aro, 1H); MS m/z (%) 245(17), 243(35), 241(29), 210(31), 208(94), 206(100), 171(20), 147(20), 145(30), 109(32), 75(24).
References:
Schann, Stephan;Greney, Hugues;Gasparik, Vincent;Dontenwill, Monique;Rascente, Carla;Lacroix, Gabriel;Monassier, Laurent;Bruban, Veronique;Feldman, Josiane;Ehrhardt, Jean-Daniel;Bousquet, Pascal [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 15,p. 4710 - 4715] Location in patent:experimental part
109384-39-6
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21709-18-2
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10468-16-3
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608-31-1
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$12.00/25g
21709-18-2
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