CC-90003 synthesis
- Product Name:CC-90003
- CAS Number:1621999-82-3
- Molecular formula:C22H21F3N6O2
- Molecular Weight:458.44
89-62-3
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1621999-82-3
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Yield:-
Steps:
Multi-step reaction with 6 steps
1.1: water / 8 h / 15 - 50 °C
1.2: 15 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; water / 3 h / 50 °C / 258.58 - 2068.65 Torr
3.1: potassium carbonate / tetrahydrofuran; water / 0.5 h / 0 - 25 °C
4.1: hydrogenchloride / methanol; water; tert-butyl methyl ether / 6.5 h / 15 - 25 °C
5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 25 h / 20 - 73 °C / Inert atmosphere
6.1: sulfuric acid / methanol / 4 h / 20 - 45 °C
6.2: 4 h / 20 - 30 °C
References:
CELGENE AVILOMICS RESEARCH, INC.;FERNANDEZ, Paul Frank;FERRETTI, Antonio Christian;HAN, Jianxin;TRAVERSE, John;TUNG, Hsien-Hsin;YONG, Kelvin Hin-Yeong;ZOU, Nanfei WO2016/187028, 2016, A1
3932-97-6
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1621999-82-3
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71894-91-2
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1621999-82-3
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