CHEMBRDG-BB 4023079 synthesis

10synthesis methods

Product Name:CHEMBRDG-BB 4023079
CAS Number:15371-15-0
Molecular formula:C7H7BrN4O2
Molecular Weight:259.06

93703-24-3
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$30.00/1g

74-88-4
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$15.00/10g

15371-15-0
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$84.00/250mg

Yield:15371-15-0 93%

Reaction Conditions:

with potassium carbonate in N-methyl-acetamide;water;

Steps:

15 Synthesis of (R)-3,7-Dimethyl-1-(5-hydroxyhexyl)-8-N-methylaminoxanthine (CT12481)

Example 15 Synthesis of (R)-3,7-Dimethyl-1-(5-hydroxyhexyl)-8-N-methylaminoxanthine (CT12481) To a stirring suspension of 8-bromo-3-methylxanthine (prepared as described above for CT12440) (12.25 g, 50.0 mmol) and potassium carbonate (8.62 g, 62.5 mmol) in dimethylformamide (150 ml) was added methyl iodide (7.81 g, 55.0 mmol). After stirring overnight at room temperature, the mixture was poured into ice cold water (400 ml) and stirred at 0-5° C. for 1 hour. The precipitate was filtered, rinsed with water (5*25 ml) and dried under vacuum to provide 8-bromo-3,7-dimethylxanthine (12.10 g, 93% yield) as a beige solid.

References:

US2002/28823,2002,A1