CHENODEOXYCHOLIC ACID SODIUM synthesis

Yield:-

Reaction Conditions:

with sodium hydroxide in ethanol;water at 20; for 1 h;

Steps:

5.2. General procedure for the synthesis of 24-hydroxy-24,24-bisphosphonobile acid disodium salts 3b-5b and bile acids disodium salts 6b-8b
General procedure: 4 mmol of the bisphosphonobile acids 3a-5a, dissolved in 20 mL of EtOH/H₂O (1:1 v/v), were treated with an aqueous solution of NaOH (8 mmol). The mixture was stirred for 1 h at r.t. The reaction mixture was lyophilized giving the expected disodium salts in almost quantitative yield.

References:

Bortolini, Olga;Fantin, Giancarlo;Fogagnolo, Marco;Rossetti, Stefano;Maiuolo, Loredana;Di Pompo, Gemma;Avnet, Sofia;Granchi, Donatella [European Journal of Medicinal Chemistry,2012,vol. 52,p. 221 - 229] Location in patent:experimental part