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chroMan-3-carbonitrile synthesis

1synthesis methods
-

Yield:89197-60-4 49 % Turnov.

Reaction Conditions:

with hydrogen;palladium on activated charcoal in ethyl acetate at 65 - 70; under 3102.9 Torr; for 24 h;

References:

Chapleo, Christopher B.;Myers, Peter L.;Butler, Richard C. M.;Davis, John A.;Doxey, John C.;et al. [Journal of Medicinal Chemistry,1984,vol. 27,# 5,p. 570 - 576]