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CINNOLINE-3-CARBOXYLIC ACID synthesis

2synthesis methods
51073-57-5 Synthesis
3-cinnolinecarboxaldehyde

51073-57-5
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Yield:90418-63-6 49%

Reaction Conditions:

with sodium chlorite;2-methyl-but-2-ene in water;tert-butyl alcohol at 20; for 1 h;

References:

Andrews, Mark D.;Af Forselles, Kerry;Beaumont, Kevin;Galan, Sébastien R. G.;Glossop, Paul A.;Grenie, Mathilde;Jessiman, Alan;Kenyon, Amy S.;Lunn, Graham;Maw, Graham;Owen, Robert M.;Pryde, David C.;Roberts, Dannielle;Tran, Thien Duc [ACS Medicinal Chemistry Letters,2015,vol. 6,# 4,p. 419 - 424] Location in patent:supporting information