ChemicalBook CAS DataBase List Cordycepin

Cordycepin synthesis

6synthesis methods

Product Name:Cordycepin
CAS Number:73-03-0
Molecular formula:C10H13N5O3
Molecular Weight:251.24

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73-03-0
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Yield:73-03-0 87%

Reaction Conditions:

Stage #1: ((2S,4R,5R)-4-acetoxy-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetatewith sodium hydroxide in methanol at 25; for 1 h;
Stage #2: with ammonium chloride in methanol; for 0.5 h;Reagent/catalyst;

Steps:

5.2

(2) Basic deacylation: To a 250 mL reaction flask, 15.0 g of Compound 5-1, 150 mL of methanol and 3.9 g of sodium hydroxide solid were added, and the reaction was stirred at 25 ° C for 1 h.5.4 g of solid ammonium chloride was added, stirred for 30 min, filtered, and the filtrate was spun dry and recrystallized to give 9.8 g of Compound 1 crystals, yield 87%.

References:

CN108676048,2018,A Location in patent:Paragraph 0074-0078

2627-64-7 Synthesis