Coumarin 343 synthesis
- Product Name:Coumarin 343
- CAS Number:55804-65-4
- Molecular formula:C16H15NO4
- Molecular Weight:285.29
55804-66-5
116 suppliers
$45.00/100mg
55804-65-4
121 suppliers
$45.00/100mg
Yield: 85%
Reaction Conditions:
with hydrogenchloride;water at 25; for 24 h;
Steps:
A solution of 3 (2.0 g, 6.38 mmol) in concentrated HCl solution(20 mL) was stirred at 25 °C for 24 h. After the reaction was completed,water (100 mL) was added to the solution. The mixture was extractedby ethyl acetate (50 mL) for three times, the combined organic layerwas washed by H2O (50 mL) and brine, dried over anhydrous Na2SO4and concentered under reduced pressure to afford compound 4 as orangesolid (1.55 g, 85%), mp 223-225 °C, 1H NMR (400 MHz DMSO-d6) δ 12.20 (bs, 1H), 8.46 (s, 1H), 7.24 (s, 1H), 2.72 (dd,J=13.2, 6.8 Hz, 4H), 2.51-2.50 (m, 4H), 1.95-1.81 (m, 4H).
References:
Ismail, Ismail;Wang, Dawei;Wang, Zhenghua;Wang, Dan;Zhang, Changyu;Yi, Long;Xi, Zhen [Dyes and Pigments,2019,vol. 163,p. 700 - 706]
63149-33-7
115 suppliers
$52.10/1g
55804-65-4
121 suppliers
$45.00/100mg
2033-24-1
665 suppliers
$6.00/25g
63149-33-7
115 suppliers
$52.10/1g
55804-65-4
121 suppliers
$45.00/100mg
107408-81-1
5 suppliers
inquiry
55804-65-4
121 suppliers
$45.00/100mg
41175-50-2
223 suppliers
$52.00/1g
55804-65-4
121 suppliers
$45.00/100mg