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ChemicalBook CAS DataBase List CYCLOBUTYLAMINE HYDROCHLORIDE

CYCLOBUTYLAMINE HYDROCHLORIDE synthesis

2synthesis methods
-

Yield: 77%

Reaction Conditions:

Stage #1:cyclobutyl amide with [bis(acetoxy)iodo]benzene;trifluoroacetic acid in water;acetonitrile for 4 h;Hofmann Rearrangement;
Stage #2: with hydrogenchloride in water

References:

Almond, Merrick R.;Stimmel, Julie B.;Thompson, E. Alan;Loudon, G. Marc [Organic Syntheses,1988,vol. 66,p. 132 - 132]

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