Cyclohexanecarboxamide, 2-hydroxy-, (1R,2S)- (9CI) synthesis
- Product Name:Cyclohexanecarboxamide, 2-hydroxy-, (1R,2S)- (9CI)
- CAS Number:454431-51-7
- Molecular formula:C7H13NO2
- Molecular Weight:143.18
4513-77-3
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Yield:> 99 % ee
Reaction Conditions:
Stage #1: 2-cyanocyclohexanonewith ketoreductase from P1-A04;NADPH;magnesium sulfate in aq. phosphate buffer;isopropyl alcohol at 30; pH=7;
Stage #2: with C12H22Cl2OPRu in isopropyl alcohol at 60; pH=5;enantioselective reaction;
References:
Liardo, Elisa;González-Fernández, Rebeca;Ríos-Lombardía, Nicolás;Morís, Francisco;García-álvarez, Joaquín;Cadierno, Victorio;Crochet, Pascale;Rebolledo, Francisca;González-Sabín, Javier [ChemCatChem,2018,vol. 10,# 20,p. 4676 - 4682]
196801-10-2
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646-20-8
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