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32045-66-2

Cyclohexanone, 2-(3-methylphenyl)- synthesis

10synthesis methods
-

Yield:32045-66-2 79%

Reaction Conditions:

Stage #1: trans-2-(3-methylphenyl)cyclohexan-1-olwith oxalyl dichloride;dimethyl sulfoxide in dichloromethane at -78; for 0.333333 h;Inert atmosphere;
Stage #2: with triethylamine in dichloromethane at -78 - 20; for 0.583333 h;Inert atmosphere;

References:

Duong, Hung A.;Gilligan, Ruth E.;Cooke, Michael L.;Phipps, Robert J.;Gaunt, Matthew J. [Angewandte Chemie - International Edition,2011,vol. 50,# 2,p. 463 - 466] Location in patent:supporting information; experimental part