Cyclohexylideneacetic acid methyl ester synthesis
- Product Name:Cyclohexylideneacetic acid methyl ester
- CAS Number:40203-74-5
- Molecular formula:C9H14O2
- Molecular Weight:154.21
108-94-1
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21204-67-1
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40203-74-5
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Yield:40203-74-5 21%
Reaction Conditions:
in toluene;Heating / reflux;
Steps:
5
Example 5Synthesis of Compound 802 To a stirred solution of cyclohexanone 801 (15.O g, 153 mmol) in toluene (100 rnL) was added methoxycarbonylmethylene triphenylphosphorane (52.8 g, 153 mmol). The reaction mixture was re fluxed overnight. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with water and brine and dried over anhydrous sodium sulfate to afford product cyclohexylidene-acetic acid methyl ester 802 (5.0 g, 21%). 1H NMR (200 MHz, CDCl3): δ 1.6-2.0 (m, 10H), 3.7 (s, 3H), 5.6(s, IH).
References:
WO2008/73623,2008,A2 Location in patent:Page/Page column 93
5927-18-4
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108-94-1
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40203-74-5
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1067-74-9
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108-94-1
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40203-74-5
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116-54-1
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108-94-1
569 suppliers
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40203-74-5
18 suppliers
$28.60/1MG
![1,2,4-Trioxaspiro[4.5]decane](/CAS/20200401/GIF/177-12-8.gif)