cyclooct-4-en-1-ol synthesis
- Product Name:cyclooct-4-en-1-ol
- CAS Number:4277-34-3
- Molecular formula:C8H14O
- Molecular Weight:126.2
![(1R,8S)-rel-9-Oxabicyclo[6.1.0]non-4-ene](/CAS/GIF/19740-90-0.gif)
19740-90-0
4277-34-3
The general procedure for the synthesis of 4-hydroxycyclooctene from 5,6-epoxycyclooctene was as follows: 1. Preparation of (Z)-epoxy-4-enol (1): 9-oxabicyclo[6.1.0]non-4-ene (4.2 g, 33.8 mmol) was slowly added to LiAlH4 (1.2 g, 30.4 mmol) suspended in ether (100 mL). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, 4 mL of H2O, 4 mL of 25% NaOH (aq) and 4 mL of H2O were added sequentially for post-treatment. The resulting mixture was filtered and the filtrate was dried with Na2SO4 and filtered again. Concentration of the clarified ether solution gave 4.1 g (Z)-cyclooct-4-enol in 96.1% yield.
111-78-4
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4277-34-3
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: 59 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature
2: 70 percent / LiAlH4 / diethyl ether / 24 h / Heating
References:
Meier, Herbert;Mayer, Winfried;Kolshorn, Heinz [Chemische Berichte,1987,vol. 120,p. 685 - 690]
31598-70-6
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4277-34-3
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111-78-4
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4277-34-3
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![HydroxylaMine, O-[(4-Methylphenyl)sulfonyl]-](/CAS/GIF/52913-14-1.gif)
52913-14-1
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4277-34-3
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