cyclopentyl(phenyl)methanamine synthesis
- Product Name:cyclopentyl(phenyl)methanamine
- CAS Number:23459-36-1
- Molecular formula:C12H17N
- Molecular Weight:175.28
83568-09-6
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23459-36-1
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Yield:23459-36-1 96.3%
Reaction Conditions:
with ammonia;hydrogen in methanol; under 26252.6 Torr;Autoclave;
Steps:
1.2 2) Reduced amination of phenylcyclopentanone oxime
In the autoclave, 1,100 ml of anhydrous methanol was added as the solvent, 185.98 g of phenylcyclopentanone oxime as a raw material and 35 g of catalyst SN-6000P. The autoclave was sealed and the kettle was replaced with air, 18 g of ammonia was introduced, The reaction is carried out while maintaining the hydrogen pressure to 3.5 MPa, and the reaction is stopped when the system is no longer absorbing hydrogen. Filtration and concentration to obtain the crude α-cyclopentyl (phenyl) methylamine; reacting the crude product with hydrochloric acid and salt with ethyl acetate (Phenyl) methylamine hydrochloride, extracted with ethyl acetate, dried and concentrated to give α-cyclopentyl (phenyl) methylamine pure product 165.66 g, this step yield 96.3%.
References:
CN106431934,2017,A Location in patent:Paragraph 0007
5422-88-8
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100-47-0
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$14.14/25gm:
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33240-34-5
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$99.00/100g
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