CYPRAZINE-DESISOPROPYL synthesis

Yield:-

Reaction Conditions:

with ammonium hydroxide in 1,4-dioxane;water;

Steps:

1.b 2-Cyclopropylamino-4,6-diamino-s-triazine

(b) 138 g of 2-cyclopropylamino-4,6-dichloro-s-triazine are added at a slightly elevated tmeperature and with vigorous stirring to a mixture of 675 ml of dioxane and 135 ml of ether. After cooling to room temperature, 101 ml of 25%, aqueous ammonia are added dropwise over a period of 20 minutes. The reaction mixture is heated to 50° C., stirred for 16 hours and then concentrated by evaporation under water jet vaccum. The dry riesidue is diluted with 500 ml. of water and after stirring for 1 hour at room temperature, the tiny white crystals formed are separated by filtering under suction and dried under water jet vacuum at 80° C. 217 g. of 2-cyclopropylamino-4-chloro-6-amino-s-triazine are obtained. Melting point 188°-189° C.

References:

US4225598,1980,A