D(-)-AC-ALPHA-PHENYLGLYCINOL synthesis
- Product Name:D(-)-AC-ALPHA-PHENYLGLYCINOL
- CAS Number:78761-26-9
- Molecular formula:C10H13NO2
- Molecular Weight:179.22
56613-80-0
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141-78-6
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78761-26-9
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$65.00/500mg
Yield:78761-26-9 91%
Reaction Conditions:
with Trimethylacetic acid at 90; for 24 h;Inert atmosphere;chemoselective reaction;
Steps:
Typical procedure for N-acetylation of primary aliphatic amines (Table 1, entry 9):
General procedure: To a solution of tBuCO2H (3d) (30.9 mg, 0.30 mmol) in EtOAc (3.0 mL) at room rtemperature was added 3-amino-1-phenylbutane (1) (48.7 μL, 0.30 mmol). The reaction mixture was refluxed (90 °C) for 24 h and then it was evaporated the solvent. The crude product was purified preparative thin layer chromatography on silica (hexane/EtOAc/35% NH3 = 25/75/1) to afford the corresponding acetoamide 2 (57.0 mg, 99% yield) as a colorless oil.
References:
Yoshida, Tomoki;Kawamura, Shimpei;Nakata, Kenya [Tetrahedron Letters,2017,vol. 58,# 12,p. 1181 - 1184] Location in patent:supporting information
![Acetamide, N-[2-(acetyloxy)-1-phenylethyl]-, (R)- (9CI)](/CAS/GIF/78761-25-8.gif)
78761-25-8
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78761-26-9
32 suppliers
$65.00/500mg
56613-80-0
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$5.00/1g
75-36-5
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$17.92/100G
78761-26-9
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$65.00/500mg
108-24-7
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56613-80-0
540 suppliers
$5.00/1g
78761-26-9
32 suppliers
$65.00/500mg
56613-80-0
540 suppliers
$5.00/1g
108-24-7
0 suppliers
$14.00/250ML
78761-26-9
32 suppliers
$65.00/500mg