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89929-33-9

DEACETYL KETOCONAZOLE synthesis

1synthesis methods
-

Yield:89929-33-9 13.9 parts (71%)

Reaction Conditions:

with potassium hydroxide in benzene;

Steps:

XXI EXAMPLE XXI

EXAMPLE XXI A mixture of 21 parts of cis-1-acetyl-4-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}piperazine, 10 parts of potassium hydroxide and 200 parts of 1-butanol is stirred and refluxed overnight. The reaction mixture is cooled and benzene is added. The whole is washed with water, dried, filtered and evaporated. The residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 13.9 parts (71%) of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-piperazine; mp. 170.7° C.

References:

US4144346,1979,A