E4,6-Dichloro-5-fluoronicotinic acid synthesis
- Product Name:E4,6-Dichloro-5-fluoronicotinic acid
- CAS Number:154012-18-7
- Molecular formula:C6H2Cl2FNO2
- Molecular Weight:209.99
6317-97-1
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$65.00/50mg
154012-18-7
65 suppliers
$41.00/100mg
Yield:-
Steps:
Multi-step reaction with 5 steps
1: 73 percent / POCl3 / 48 h / 115 °C
2: 94 percent / H2 / Raney-nickel / tetrahydrofuran / 21 h / 26 - 34 °C / 1241.2 - 2585.7 Torr
3: 91 percent / hexafluorophosphoric acid, aq. NaNO2 / 0.08 h
4: 27 percent / 150 °C
5: 97 percent / 1.0 N aq. NaOH / tetrahydrofuran / 0.5 h / 5 - 20 °C
References:
Sanchez;Gogliotti [Journal of Heterocyclic Chemistry,1993,vol. 30,# 4,p. 855 - 859]
154012-17-6
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$116.64/100mgs:
154012-18-7
65 suppliers
$41.00/100mg
154012-15-4
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154012-18-7
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$41.00/100mg
154012-16-5
37 suppliers
$279.23/1gm:
154012-18-7
65 suppliers
$41.00/100mg