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Ethanone, 1-(3-hydroxy-2-methylphenyl)- (9CI) synthesis

3synthesis methods
Preparation by diazotization of 6-amino-3-hydroxy-2- methylacetophenone, followed by hydrolysis of the obtained diazonium salt in the presence of hypophosphorous acid at 0° (42%).
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Yield:69976-81-4 86%

Reaction Conditions:

with aluminum (III) chloride in chlorobenzene; for 5 h;Reflux;

References:

Qian, Yong;Schürmann, Marc;Janning, Petra;Hedberg, Christian;Waldmann, Herbert [Angewandte Chemie - International Edition,2016,vol. 55,# 27,p. 7766 - 7771][Angew. Chem.,2016,vol. 128,p. 7897 - 7902] Location in patent:supporting information