Ethanone, 1-(5-amino-2-methoxyphenyl)- (9CI) synthesis
- Product Name:Ethanone, 1-(5-amino-2-methoxyphenyl)- (9CI)
- CAS Number:85276-70-6
- Molecular formula:C9H11NO2
- Molecular Weight:165.19
51410-09-4
15 suppliers
$52.50/250mg
85276-70-6
8 suppliers
inquiry
Yield:85276-70-6 99%
Reaction Conditions:
with hydrogenchloride in ethanol;water;
Steps:
1.ii (ii)
(ii) 1-(5-Amino-2-methoxyphenyl)ethanone Hydrochloric acid (6M, 50 ml) was added to a mixture of N-(3-acetyl-4-methoxyphenyl)acetamide (10.34 g, 50 mmol) and ethanol (150 ml) and the mixture was stirred under reflux for 8 hours. The mixture was cooled and the solvent was evaporated under reduced pressure. Water (100 ml) was added and the pH was adjusted to 10.0 with saturated aqueous potassium carbonate. The mixture was extracted with dichloromethane (3*100 ml) and the combined organic fractions were dried (MgSO4) and evaporated under reduced pressure to give 1-(5-amino-2-methoxyphenyl)ethanone as a dark oil (8.16 g, 99%), 1 H NMR (CDCl3) δ 7.09 (1H, d, J=2.8 Hz), 6.82 (2H, m), 3.84 (3H, s), and 3.34 (2H, br. s), 2.59 (3H, s). m/e (CI+) 166 (MH+).
References:
US6096766,2000,A
61941-46-6
15 suppliers
$45.00/10mg
85276-70-6
8 suppliers
inquiry
2516-96-3
461 suppliers
$6.00/25g
85276-70-6
8 suppliers
inquiry
40751-89-1
81 suppliers
$7.00/250mg
85276-70-6
8 suppliers
inquiry
90763-46-5
0 suppliers
inquiry
85276-70-6
8 suppliers
inquiry