Ethanone, 1-(5-thiazolyl)- (9CI) synthesis
- Product Name:Ethanone, 1-(5-thiazolyl)- (9CI)
- CAS Number:91516-28-8
- Molecular formula:C5H5NOS
- Molecular Weight:127.16
898825-89-3
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$100.00/1g
75-16-1
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$12.00/10ml
91516-28-8
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$98.00/1g
Yield:91516-28-8 90%
Reaction Conditions:
in tetrahydrofuran;diethyl ether at -10 - 20; for 16.16 h;Inert atmosphere;
Steps:
30 [000368j Synthesis of 1-(thiazol-5-yl) ethan-1-one (452):
[000368] Synthesis of 1-(thiazol-5-yl) ethan-1-one (452): To a stirred solution of compound 451 (1.2 g, 6.97 mmol) in THF (20 mL) under argon atmosphere was added methyl magnesium bromide (3.2 mL,10.46 mmol, 3 M solution in Et20) dropwise for 10 mm at -10 °C; warmed to RT and stirred for 16 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was quenched with saturated ammonium chloride (30 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain the crude. The crude was purified through combi flash chromatography using 25-30% EtOAc/ hexanes to afford compound 452 (800 mg, 90%) as white solid. TLC: 50% EtOAc/ hexanes (R 0.6); 1H NMR (DMSO-d6, 400 MHz): ? 9.40 (s, 1H), 8.71 (s, 1H), 2.60 (s, 3H).
References:
WO2015/138895,2015,A1 Location in patent:Paragraph 000368
898825-89-3
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$100.00/1g
91516-28-8
50 suppliers
$98.00/1g
79265-36-4
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$28.00/250mg
75-36-5
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$17.92/100G
91516-28-8
50 suppliers
$98.00/1g
