ChemicalBook CAS DataBase List Ethyl 2-(4-Oxocyclohexyl)propanoate

Ethyl 2-(4-Oxocyclohexyl)propanoate synthesis

4synthesis methods

Product Name:Ethyl 2-(4-Oxocyclohexyl)propanoate
CAS Number:31180-85-5
Molecular formula:C11H18O3
Molecular Weight:198.2588

Ethyl 2-(1,4-Dioxaspiro[4.5]decan-8-yl)propanoate

31180-84-4
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31180-85-5
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Yield:31180-85-5 91.5%

Reaction Conditions:

with hydrogenchloride in acetone at 20; for 24 h;Concentration;

Steps:

Intermediate 27C: racemic ethyl 2-(4-oxocyclohexyl)propanoate

A racemic mixture of Intermediate 27B (17.1 g, 70.6 mmol) was dissolved in acetone (250 mL). Then 1 N aq. HC1 (62 mL) was added and the mixture was stirred at room temperature for 24 hours. The mixture was concentrated under reduced pressure and extracted with EtOAc (200 mL x 3). The combined organic extracts were washed with 1 N aq. NaOH (50 mL), dried over anhydrous MgS0₄, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (0-20% EtOAc in petroleum ether) to afford Intermediate 27C (12.8 g, 91.5% yield).

References:

WO2016/73770,2016,A1 Location in patent:Paragraph 0287

4746-97-8 Synthesis

4746-97-8
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$5.00/1g

31180-85-5
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References

ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)propanoate

19620-33-8
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31180-85-5
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References

3699-66-9 Synthesis

3699-66-9
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31180-85-5
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References