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217965-54-3

Ethyl 2-(azepan-2-yl)acetate synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C
1.2: 0.17 h / -78 °C
2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
2.2: 2 h / -78 - 20 °C

References:

Kim, Jae Hyun;Paul, Anirudra;Ghiviriga, Ion;Seidel, Daniel [Organic Letters,2021,vol. 23,# 3,p. 797 - 801]