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ETHYL 2-ISOCYANATO-3-METHYLBUTYRATE synthesis

3synthesis methods
-

Yield:-

Reaction Conditions:

Stage #1: valine ethyl esterwith hydrogenchloride for 0.5 h;
Stage #2: phosgene at 20; for 12 h;

References:

Wattanasin, Sompong;Weidmann, Beat;Roche, Didier;Myers, Stewart;Xing, Amy;Guo, Qin;Sabio, Michael;Von Matt, Peter;Hugo, Ronald;Maida, Susan;Lake, Philip;Weetall, Marla [Bioorganic and Medicinal Chemistry Letters,2001,vol. 11,# 22,p. 2955 - 2958]

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