Ethyl 4-broMo-2,2-diMethylacetoacetate synthesis

Yield:63891-88-3 98%

Reaction Conditions:

with copper(ll) bromide in chloroform;ethyl acetate; for 24 h;Product distribution / selectivity;Heating / reflux;

Steps:

1

Intermediate 115: Preparation of ethyl 4-bromo-2,2-dimethyl-3-oxobutanoateMethod 1: To a solution of intermediate 114 (250 mg, 1.58 mmol) in ethyl acetate-chloroform (9 ml, 3:1), cupric bromide (1.06 gm, 4.74 mmol) was added and stirred at reflux temperature for 24 h. The reaction mixture was filtered through celite and celite was washed with ethyl acetate. The filtrate and washings were combined and washed successively with water and brine and dried over Na₂SO₄. The solvent was evaporated to give a yellow oil (370 mg, 98%).

References:

US2008/200501,2008,A1 Location in patent:Page/Page column 44