ethyl 5,5-dimethoxy-2,4-dioxopentanoate synthesis
1synthesis methods
- Product Name:ethyl 5,5-dimethoxy-2,4-dioxopentanoate
- CAS Number:108630-69-9
- Molecular formula:C9H14O6
- Molecular Weight:218.2
Yield:108630-69-9 81%
Reaction Conditions:
with sodium ethanolate in ethanol at 20; for 2 h;
Steps:
Intermediate ISa: Ethyl 5,5-dimethoxy-2,4-dioxopentanoate
To a solution of i,i-dimethoxypropan-2-one (1.0 g, 8.0 mmol) and diethyl ethanedioate (1.48 g, 10.0 mmol) in dry ethanol, a freshly prepared sodium ethoxide solution in ethanol was added at room temperature and stirred for 2 h. The reaction mixture was concentrated and the obtained title product (4.0 g, 81.0%), which wasused as such for the next step.
References:
WO2014/202580,2014,A1 Location in patent:Page/Page column 87