ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE synthesis
- Product Name:ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE
- CAS Number:545394-60-3
- Molecular formula:C13H19NO2
- Molecular Weight:221.3
Yield:-
Reaction Conditions:
with ammonium persulfate;aq. sulfuric acid;silver nitrate
Steps:
75.a (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enamide
(a) Ethyl 6-(tert-butyl)-2-methylpyridine-3-carboxylate. Analogous to the procedure used to prepare Example 44, step (a), ethyl 2-methylnicotinate (8.3 g, 50 mmol, Aldrich), trimethylacetic acid (26 g, 250 mmol, Aldrich), silver nitrate (1.7 g, 10 mmol, Aldrich), 10% aq. sulfuric acid (50 mL) and ammonium persulfate (23 g, 100 mmol, Aldrich) provided, after purification by silica gel chromatography (80:20 hexane:EtOAc), the title product. MS (ESI, pos. ion) m/z: 222 (M+1).
References:
US2003/195201,2003,A1
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