ChemicalBook CAS DataBase List ETHYL ISONICOTINOYLACETATE

ETHYL ISONICOTINOYLACETATE synthesis

11synthesis methods

Product Name:ETHYL ISONICOTINOYLACETATE
CAS Number:26377-17-3
Molecular formula:C10H11NO3
Molecular Weight:193.2

1570-45-2 Synthesis

1570-45-2
371 suppliers
$7.00/10g

141-78-6 Synthesis

141-78-6
590 suppliers
$20.50/250ml

26377-17-3
166 suppliers
$6.00/250mg

141-97-9 Synthesis

141-97-9
764 suppliers
$5.00/25g

Yield: 87%

Reaction Conditions:

with lithium hexamethyldisilazane in tetrahydrofuran at -40; for 0.333333 h;Inert atmosphere;Claisen condensation;

Steps:

General procedure to synthesis β-keto esters from the corresponding esters
General procedure: To the solution of ester (10 mmol) in THF (20 mL) and ethyl acetate (70 mmol), LiHMDS (30 mmol) was added very quickly at -40 °C, and stirred at this temperature for 20 min. After completion of the reaction, reaction mixture was quenched with acetic acid (50 mmol) and then basified using 10% NaHCO₃solution, extracted with ethyl acetate (2×100 mL), the combined organic layer was washed with water and brine solution and dried over Na₂SO_4. The specific purification procedure for each compound has been included along with their characterization data.

References:

Venkat Ragavan;Vijayakumar;Rajesh;Palakshi Reddy;Karthikeyan;Suchetha Kumari [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 12,p. 4193 - 4197] Location in patent:supporting information; experimental part

1570-45-2 Synthesis

1570-45-2
371 suppliers
$7.00/10g

141-78-6 Synthesis

141-78-6
590 suppliers
$20.50/250ml

26377-17-3
166 suppliers
$6.00/250mg

References

55-22-1 Synthesis